Master donor viruses A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortants used in live attenuated influenza vaccine (LAIV) do not display neurovirulent properties in a mouse model
Identifieur interne : 000F44 ( Main/Exploration ); précédent : 000F43; suivant : 000F45Master donor viruses A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortants used in live attenuated influenza vaccine (LAIV) do not display neurovirulent properties in a mouse model
Auteurs : J. Theo M. Voeten [Pays-Bas] ; Irina V. Kiseleva [Pays-Bas, Russie] ; Harrie L. Glansbeek [Pays-Bas] ; Stephanie M. C. Basten [Pays-Bas] ; Sandra K. M. Drieszen-Van Der Cruijsen [Pays-Bas] ; Larisa G. Rudenko [Russie] ; Han Van Den Bosch [Pays-Bas] ; Jacco G. M. Heldens [Pays-Bas]Source :
- Archives of Virology [ 0304-8608 ] ; 2010-09-01.
Descripteurs français
- KwdFr :
- Animaux, Chiens, Embryon de poulet, Encéphale (anatomopathologie), Encéphale (virologie), Femelle, Grippe humaine (), Grippe humaine (anatomopathologie), Grippe humaine (virologie), Humains, Lignée cellulaire, Modèles animaux de maladie humaine, Souris, Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (immunologie), Sous-type H2N2 du virus de la grippe A (pathogénicité), Sous-type H2N2 du virus de la grippe A (physiologie), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (génétique), Vaccins antigrippaux (immunologie), Vaccins atténués (administration et posologie), Vaccins atténués (génétique), Vaccins atténués (immunologie), Virulence, Virus influenza B (génétique), Virus influenza B (immunologie), Virus influenza B (pathogénicité), Virus influenza B (physiologie), Virus recombinants (génétique), Virus recombinants (immunologie), Virus recombinants (pathogénicité), Virus recombinants (physiologie).
- MESH :
- administration et posologie : Vaccins antigrippaux, Vaccins atténués.
- anatomopathologie : Encéphale, Grippe humaine.
- génétique : Sous-type H2N2 du virus de la grippe A, Vaccins antigrippaux, Vaccins atténués, Virus influenza B, Virus recombinants.
- immunologie : Sous-type H2N2 du virus de la grippe A, Vaccins antigrippaux, Vaccins atténués, Virus influenza B, Virus recombinants.
- pathogénicité : Sous-type H2N2 du virus de la grippe A, Virus influenza B, Virus recombinants.
- physiologie : Sous-type H2N2 du virus de la grippe A, Virus influenza B, Virus recombinants.
- virologie : Encéphale, Grippe humaine.
- Animaux, Chiens, Embryon de poulet, Femelle, Grippe humaine, Humains, Lignée cellulaire, Modèles animaux de maladie humaine, Souris, Virulence.
English descriptors
- KwdEn :
- Animals, Brain (pathology), Brain (virology), Cell Line, Chick Embryo, Disease Models, Animal, Dogs, Female, Humans, Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (immunology), Influenza A Virus, H2N2 Subtype (pathogenicity), Influenza A Virus, H2N2 Subtype (physiology), Influenza B virus (genetics), Influenza B virus (immunology), Influenza B virus (pathogenicity), Influenza B virus (physiology), Influenza Vaccines (administration & dosage), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Influenza, Human (pathology), Influenza, Human (prevention & control), Influenza, Human (virology), Mice, Reassortant Viruses (genetics), Reassortant Viruses (immunology), Reassortant Viruses (pathogenicity), Reassortant Viruses (physiology), Vaccines, Attenuated (administration & dosage), Vaccines, Attenuated (genetics), Vaccines, Attenuated (immunology), Virulence.
- MESH :
- chemical , administration & dosage : Influenza Vaccines, Vaccines, Attenuated.
- genetics : Influenza A Virus, H2N2 Subtype, Influenza B virus, Influenza Vaccines, Reassortant Viruses, Vaccines, Attenuated.
- immunology : Influenza A Virus, H2N2 Subtype, Influenza B virus, Influenza Vaccines, Reassortant Viruses, Vaccines, Attenuated.
- pathogenicity : Influenza A Virus, H2N2 Subtype, Influenza B virus, Reassortant Viruses.
- pathology : Brain, Influenza, Human.
- physiology : Influenza A Virus, H2N2 Subtype, Influenza B virus, Reassortant Viruses.
- prevention & control : Influenza, Human.
- virology : Brain, Influenza, Human.
- Animals, Cell Line, Chick Embryo, Disease Models, Animal, Dogs, Female, Humans, Mice, Virulence.
Abstract
Abstract: Demonstration of the absence of neurovirulent properties of reassortant viruses contained in live attenuated influenza vaccine (LAIV) is a regulatory requirement. A mouse model was used to detect neurovirulent properties of the cold-adapted, temperature-sensitive and attenuated influenza master donor viruses (MDVs) A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortant influenza viruses. A/NWS/33 (H1N1), which is known to be neurovirulent in mice, was used as a positive control. Under conditions where the positive control virus induced symptoms of disease and showed viral replication in the upper respiratory tract as well as in the brain, replication of the influenza master donor viruses and reassortant influenza A and B viruses was limited to the upper respiratory tract where they were administered. None of the mice inoculated with MDVs or reassortant influenza viruses suffered from disease, and no virus or viral replication was observed in the brains of these mice. The results demonstrate the absence of neurovirulent properties of the MDVs and reassortant influenza viruses derived therefrom used in LAIV.
Url:
DOI: 10.1007/s00705-010-0719-8
Affiliations:
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Le document en format XML
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grippe A (pathogénicité)</term><term>Sous-type H2N2 du virus de la grippe A (physiologie)</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Vaccins antigrippaux (génétique)</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins atténués (administration et posologie)</term><term>Vaccins atténués (génétique)</term><term>Vaccins atténués (immunologie)</term><term>Virulence</term><term>Virus influenza B (génétique)</term><term>Virus influenza B (immunologie)</term><term>Virus influenza B (pathogénicité)</term><term>Virus influenza B (physiologie)</term><term>Virus recombinants (génétique)</term><term>Virus recombinants (immunologie)</term><term>Virus recombinants (pathogénicité)</term><term>Virus recombinants (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" qualifier="administration et 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Subtype</term><term>Influenza B virus</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Encéphale</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Brain</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Chick Embryo</term><term>Disease Models, Animal</term><term>Dogs</term><term>Female</term><term>Humans</term><term>Mice</term><term>Virulence</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Chiens</term><term>Embryon de poulet</term><term>Femelle</term><term>Grippe humaine</term><term>Humains</term><term>Lignée cellulaire</term><term>Modèles animaux de maladie humaine</term><term>Souris</term><term>Virulence</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Demonstration of the absence of neurovirulent properties of reassortant viruses contained in live attenuated influenza vaccine (LAIV) is a regulatory requirement. A mouse model was used to detect neurovirulent properties of the cold-adapted, temperature-sensitive and attenuated influenza master donor viruses (MDVs) A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortant influenza viruses. A/NWS/33 (H1N1), which is known to be neurovirulent in mice, was used as a positive control. Under conditions where the positive control virus induced symptoms of disease and showed viral replication in the upper respiratory tract as well as in the brain, replication of the influenza master donor viruses and reassortant influenza A and B viruses was limited to the upper respiratory tract where they were administered. None of the mice inoculated with MDVs or reassortant influenza viruses suffered from disease, and no virus or viral replication was observed in the brains of these mice. The results demonstrate the absence of neurovirulent properties of the MDVs and reassortant influenza viruses derived therefrom used in LAIV.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li><li>Russie</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Voeten, J Theo M" sort="Voeten, J Theo M" uniqKey="Voeten J" first="J. Theo M." last="Voeten">J. Theo M. Voeten</name></noRegion><name sortKey="Basten, Stephanie M C" sort="Basten, Stephanie M C" uniqKey="Basten S" first="Stephanie M. C." last="Basten">Stephanie M. C. Basten</name><name sortKey="Drieszen Van Der Cruijsen, Sandra K M" sort="Drieszen Van Der Cruijsen, Sandra K M" uniqKey="Drieszen Van Der Cruijsen S" first="Sandra K. M." last="Drieszen-Van Der Cruijsen">Sandra K. M. Drieszen-Van Der Cruijsen</name><name sortKey="Glansbeek, Harrie L" sort="Glansbeek, Harrie L" uniqKey="Glansbeek H" first="Harrie L." last="Glansbeek">Harrie L. Glansbeek</name><name sortKey="Heldens, Jacco G M" sort="Heldens, Jacco G M" uniqKey="Heldens J" first="Jacco G. M." last="Heldens">Jacco G. M. Heldens</name><name sortKey="Kiseleva, Irina V" sort="Kiseleva, Irina V" uniqKey="Kiseleva I" first="Irina V." last="Kiseleva">Irina V. Kiseleva</name><name sortKey="Van Den Bosch, Han" sort="Van Den Bosch, Han" uniqKey="Van Den Bosch H" first="Han" last="Van Den Bosch">Han Van Den Bosch</name></country><country name="Russie"><noRegion><name sortKey="Kiseleva, Irina V" sort="Kiseleva, Irina V" uniqKey="Kiseleva I" first="Irina V." last="Kiseleva">Irina V. Kiseleva</name></noRegion><name sortKey="Rudenko, Larisa G" sort="Rudenko, Larisa G" uniqKey="Rudenko L" first="Larisa G." last="Rudenko">Larisa G. Rudenko</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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